Overmethylated - help me

Pretty Q wrote:Area-1255,

Do you think complex amino acid tablets can help me to increase my histamine? It has 1600 mg histidine in it.

I can't buy histidine because I dont live in USA and my country doesnt allow supplements from Amazon, etc.

Pretty Q wrote:Area-1255,

I was tested for MTHFR and found I have mutation!

mthfr a1298c homozygous

Do you know what should I do? What supplement should I take and how?

Area-1255 wrote:

Pretty Q wrote:Area-1255,

I was tested for MTHFR and found I have mutation!

mthfr a1298c homozygous

Do you know what should I do? What supplement should I take and how?

Well that was pretty fast! When were you tested?
I'm sure there is some supplement company in or near your country where they can sell you L-Histidine, its a pretty simple amino acid...

If you have this mutation, it makes sense you are having these issues, but it also means you would want L-methylfolate instead of regular folic acid, but at gentle doses to start, and your dopamine and melatonin are probably low, in part due to compensatory changes in the neurotransmitter system, its also possible you have increased reuptake of Dopamine or increased dopamine transporters (DAT). You may want to look into something like Catuaba.

kpavel wrote:how's your motivation to eat?) motivation is a complex thing

Pretty Q wrote:I want to say something. I have a blood test when I was overtraining in 2015 and my basophil count was high and my testosterone is low.

Sometimes, I was overtrained and it increased my libido. I was thinking this is because estrogen. But I was wrong. It is because histamine. But I wonder why overtraining increases my histamine?

Pretty Q wrote:I want to say something. I have a blood test when I was overtraining in 2015 and my basophil count was high and my testosterone is low.

Sometimes, I was overtrained and it increased my libido. I was thinking this is because estrogen. But I was wrong. It is because histamine. But I wonder why overtraining increases my histamine?

kpavel wrote:

Pretty Q wrote:I want to say something. I have a blood test when I was overtraining in 2015 and my basophil count was high and my testosterone is low.

Sometimes, I was overtrained and it increased my libido. I was thinking this is because estrogen. But I was wrong. It is because histamine. But I wonder why overtraining increases my histamine?

During exercise, including overtraining, there's a temporary change in immune system. I suggest if your immune system is functional and strong and restores its balance then you will have a surge of libido.

For example: tnf alpha is generally very bad, and il-10 is likely good.

PLoS One. 2013 Apr 18;8(4):e61466. doi: 10.1371/journal.pone.0061466. Print 2013.
Negative association between testosterone concentration and inflammatory markers in young men: a nested cross-sectional study.
Bobjer J1, Katrinaki M, Tsatsanis C, Lundberg Giwercman Y, Giwercman A.
Author information
Abstract
OBJECTIVE:
Low grade systemic inflammation (LGSI) as well as androgen deficiency has in older men been associated with several pathologies, including cardiovascular disease (CVD). We wanted to investigate whether low testosterone levels are linked to biomarkers of LGSI already in young age, before any concurrent manifestations of CVD or other systemic diseases.
DESIGN:
Nested cross-sectional study.
METHODS:
Forty subfertile biochemically hypogonadal (n = 20) or eugonadal (n = 20) men (mean age 37 years, SD = 4.3) and 20 age-matched controls were randomly selected from an ongoing study on male subfertility. Subjects comprised male partners in infertile couples in whom also subnormal sperm concentration was present. Blood sampling, interviews, and anthropometric measures were undertaken. Serum levels of testosterone, LH, estradiol, SHBG, and 21 LGSI-markers were assessed.
RESULTS:
Among 21 inflammatory markers, macrophage inflammatory protein 1-alpha (MIP1a) (ß = -0.025; p = 0.028), 1-beta (MIP1B) (ß = -0.015; p = 0.049) and tumor necrosis factor alpha (TNFa) (ß = -0.015; p = 0.040) showed negative association to total testosterone (TT) levels. MIP1a (ß = -1.95; p = 0.001) and TNFa (ß = -0.95; p = 0.014) showed negative association to calculated free testosterone (cFT) levels. Compared to men with normal TT and cFT levels, TNFa levels were higher in men with subnormal levels of TT (mean ratio 1.61; p = 0.006) and cFT (mean ratio 1.58; p = 0.007). Also, MIP1a levels were higher in men with subnormal levels of TT  (mean ratio 1.84; p = 0.030).
CONCLUSIONS:
Subnormal testosterone may already in young age associate to LGSI, which might be a part of the mechanism underlying adverse health outcomes of male hypogonadism.
PMID: 23637840 PMCID: PMC3630214 DOI: 10.1371/journal.pone.0061466

Pretty Q wrote:Area-1255,

How is my strategy for low histamine?

NAC 600 mg + 200 mg Vitamin C
Niacin 100 mg
Folic acid 5 mg
Zinc 30 mg
5 billion probiotic

By the way, are you histadelic?

Area-1255 wrote:

Pretty Q wrote:Area-1255,

How is my strategy for low histamine?

NAC 600 mg + 200 mg Vitamin C
Niacin 100 mg
Folic acid 5 mg
Zinc 30 mg
5 billion probiotic

By the way, are you histadelic?

Why NAC? I mean, it might help but IMO is not necessary. Good for liver health though.

Add 2,000 mg or 2 grams of L-Histidine. Take once per day. One time per day.

Take the L-Histidine on an empty stomach.
Eat high amounts of Protein; fish and steak or at least EGGS should be included.
Get plenty of rest each night.

Add those steps and you should be good.

I have ''normal'' histamine levels but I believe I come from a high-histamine family.

Pretty Q wrote:

Area-1255 wrote:

Pretty Q wrote:Area-1255,

How is my strategy for low histamine?

NAC 600 mg + 200 mg Vitamin C
Niacin 100 mg
Folic acid 5 mg
Zinc 30 mg
5 billion probiotic

By the way, are you histadelic?

Why NAC? I mean, it might help but IMO is not necessary. Good for liver health though.

Add 2,000 mg or 2 grams of L-Histidine. Take once per day. One time per day.

Take the L-Histidine on an empty stomach.
Eat high amounts of Protein; fish and steak or at least EGGS should be included.
Get plenty of rest each night.

Add those steps and you should be good.

I have ''normal'' histamine levels but I believe I come from a high-histamine family.

Seems like you have high "brain" histamine. Your libido and motivation is high?