Rebalancing the NMDA signalling

Reading a bit about 5ht1a, made me look at nmda and glutamate signalling. For now, I’m pretty far from any conclusion thanks to that I don’t have any free time and to my cognitive abilities heavily affected.

Firstly, I had thought that I have something like glutamate excitotoxicity. Look at the huntington symptoms, I have all of these. Motor disturbances are so rare or do not exist in pssd as so far I see. And people do no worsening like me. I started to trembling randomly a few days ago. I don’t think I have much time before I go full brain dead.

Then, I have look up to the low glutamate/nmda signalling symptoms. And, they are much more familiar. Little to no anxiety or depression. I can’t feel the tastes of foods. I have all of the symptoms of high GABA. high blood pressure. Extreme hypersomnia, etc.

May I take some help here? I guess it’s dangerous to play with glutamate or nmda, so I must be too careful. On the other side, I’m very restricted when it comes to supplements.

Flaxseed oil may lower quinolinic/kynurenic ratio and lower blood pressure. Celery seed, olive leaf lower blood pressure.

you have low cortisol, did you measure iron or b12?
iron may raise nmda density and cortisol secretion

My B12 is about 500-550. I didn’t measure iron.

Iron has such a bad reputation on raypeatforum. If it works, I can eat iron rich foods.

Any other recommendation?

I usually prefer to eat pomegranate while sitting at computer desk.
May help similar to omega 3. And I avoid milk products. By the way propionic acid is used to prolong its life with microbes. See McFabe research.
https://www.phcogj.com/article/633

I started to drink pomegranate juice. I hope it gives some benefit.

But I don't think it will give me real effect, though.

I need a really effective way to balance my NMDA(glutamate)/GABA.

In my case, even that I'm not so sure, I think I have to increase the glutamate/nmda.

I do have improvements with my approach. Less stress, less spaciness, better mood, more energy and less mistakes. No signigicant change in excitation in sense of libido though but much less anger definitely.

NMDA makes sense but practice is not so optimistic. More complex interactions need to be solved.
Although big pharma made a big study on this theme. And epileptical/bipolar drugs often make people to claim better/worse libido. Lithium, lamotrigine, valproate, carbamazepine.
https://www.ncbi.nlm.nih.gov/pubmed/19295509/

I guess I have to find these big interactions as fast as possible.

I look into lithium and other drugs you mentioned but they just seemed too dangerous to me.

I want to explain you my theory (not actually a theory):

I stumbled on the Huntington Disease a few days ago. I read about it on the wikipedia, and a bit on the pubmed. I would absolutely be gratefull if you read the wikipedia page about it. Becasue it exactly explains my situation.

So, I looked up to some of the mechanisms contributing to huntington disease. I saw that glutamate excitoxicity-neuronal loss plays a role.

I just said that I have nmda hypofunction symptoms. But I’m progressively worsening and also I have all the symptoms of huntington disease. I just thought that maybe excess nmda signalling may cause internalization of nmda receptors. Or it just kills my brain cells and it’s the reason why I became incredibly stupid and my anxiety have erased.

SSRI gave me something like huntington disease. It’s NMDA, I believe. But I need a help to conclude on something.

- Excess GABA symptoms
- Low NMDA Symptoms
- Huntington disease symptoms (myclonic jerks has started this week.)
- It worsen especially after caffeine and masturbation
- caffeine doesn’t have any boosting effect anymore. Constant hypersomnia

For now, I only have pomengranate juice and ceyloan cinnamon. Althought, I don’t want to use cinnamon until I become sure that I didn’t excitotoxicated.

get flaxseed oil, it's should be easy
estrogen protects from excitotoxicity of NMDA but who knows
iron measure may be of use even in this bad case, but I don't know much of Huntington's or Parkinson's differences, you can easily mix symptoms, like you did for MS
https://en.wikipedia.org/wiki/Myoclonic_epilepsy
pomegranate is helpful, a good habit
https://www.ncbi.nlm.nih.gov/pubmed/21776259
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181681/
I think cholinergic system plays a big role. Sweating, gaba modulation, and ton of positive things possible. NGF improves ChAT.

Area had said that kynurenic pathway takes a role on this disease. It’s really awesome to learn it.

https://www.ncbi.nlm.nih.gov/m/pubmed/21660485/

Kynurenic acid is a NMDA antagonist!!


https://hackstasis.com/threads/i’m-highly-suspecting-from-nmda-imbalance.1539/#post-49670

I started to use B complex and mk-7 by the suggestion of helen on the hackstasis but I don’t think it will help me in this way. May you give me more information about what should I do further? Modulating enzyme pathways and rebalancing the kynurenic acid, it seems a really good method!

Ciprofloxacin wrote:Area had said that kynurenic pathway takes a role on this disease. It’s really awesome to learn it.

https://www.ncbi.nlm.nih.gov/m/pubmed/21660485/

Kynurenic acid is a NMDA antagonist!!


https://hackstasis.com/threads/i’m-highly-suspecting-from-nmda-imbalance.1539/#post-49670

I started to use B complex and mk-7 by the suggestion of helen on the hackstasis but I don’t think it will help me in this way. May you give me more information about what should I do further? Modulating enzyme pathways and rebalancing the kynurenic acid, it seems a really good method!

I remember I mentioned that omega 3 change kynurenic/quinolinic acids ratio. So basically fats highly influence this. I cannot tell you for sure what ssris do because they are very little criticized in pubmed and even some negative moments are narrowed to be minor cases. But I remember a study where NSAIDs are said to reduce their 'antidepressive' action) Problem is also in that earlier scientists measured immobility instead of sugar consumption.

Better stop any caffeine including chocolate, milk. And look for something cholinergic and anti-gabe, like Ginkgo or Eleuthero. You can find something else from herbs. That will help the community.