excess serotonin

Caravaggio wrote:If you had too high cortisol you'd look like Stay Puft Marshmallow Man from Ghostbusters due to Cushing's Syndrome.

Farshad wrote:do you guys have an article on best supplements that decrease cortisol?

Farshad wrote:Question about phosphatidylserine . I saw a comment on reddit about phosphatidylserine and it said:

´´ studies to date have used the bovine cortex PS. Studies have not been done on the soy derived PS which I think is all that is available to buy.´´

is this true? I bought Jarrow Formulas, PS100, Phosphatidylserine. Not sure what its derived from


also here are some suggestions for the ways to reduce cortisol for the article:
rhodiola rosea  
Ashwagandha
Phosphatidylserine
Holy Basil
relora

let me know when its out .

Farshad wrote:cool. What intrested me is you say there are only 5 supplements/herbs that have been proven to reduce cortisol significally?  could you not find anything else?  

wouldnt basically any adaptogen herbs reduce stress/cortisol ie panax ginseng? perhaps they are not as significant as aswghanda, rhodiola, holy basil  ?

btw I read your ACTH article gonna try  out Ginkgo Biloba and Hibiscus Sabdariffa.

One such adaptogen is eleuthero (Eleutherococcus senticosus), formerly known as Siberian ginseng. Studies demonstrate that the compounds in eleuthero, especially eleutheroside E and syringin, support adrenal function by decreasing adrenal hypertrophy, blunting fatigue induced by sleep deprivation, bolstering immunity, and inhibiting elevated cortisol levels in response to stress.32,33

Farshad wrote:

One such adaptogen is eleuthero (Eleutherococcus senticosus), formerly known as Siberian ginseng. Studies demonstrate that the compounds in eleuthero, especially eleutheroside E and syringin, support adrenal function by decreasing adrenal hypertrophy, blunting fatigue induced by sleep deprivation, bolstering immunity, and inhibiting elevated cortisol levels in response to stress.32,33

thoughts?

doesent l-glycine reduce cortisol?

and  2,5 gram lysine + 2,5 gram arginine reduces cortisol I think.

Farshad wrote:so I took aswghanda, rhodiola, holy basil, Phosphatidylserine and relora at the same time.
I did feel a calm sensation hit me. went to the gym. little more confident thats it.

It feels like my thyorid are swollen right now ( i suffer from thyroid fatigue + HPA axis dysfunction) and im hoping the swolling means my thyroid are restoring or rebalancing . Like my throat it feels like theres something at my adams apple . Also I spit out a little blood. maybe related to thyroid?

rs4590408 linked to the gene LOC105375650. Your genotype is GG, which is observed in 1% of all individuals reported.
What the science suggests:
Your genotype (GG) is potentially associated with:
0.2255 unit increase for 5-Hiaa Measurement (R)
0.2255 unit increase for Hva Measurement (R)
0.2245 unit increase for Hva Measurement (R)

quantification of 5-hydroxyindoleacetic acid in cerebrospinal fluid or urine. 5-HIAA is a metabolite of serotonin. This measurement is performed during diagnosis of serotonin secreting neuroendocrine tumours. Low levels of 5-HIAA in the cerebrospinal fluid have been associated with aggressive behavior and suicide by violent means, correlating with diminished serotonin levels. Elevated serotonin (hyperserotonemia) is one of the most common biological findings in autism[3] and 5-HIAA may be elevated in patients with autistic spectrum disorders.

Farshad wrote:anyway thanks for both of you guys help . Ive learned so much. gonna continue  my journey somewhere else -
if anyone cares ; http://www.longecity.org/forum/topic/100224-need-help-with-cortisol-mutations/

Im over the high serotonin stuff .

Farshad wrote:anyway thanks for both of you guys help . Ive learned so much. gonna continue  my journey somewhere else -
if anyone cares ; http://www.longecity.org/forum/topic/100224-need-help-with-cortisol-mutations/

Im over the high serotonin stuff .

Farshad wrote:best sleep ive had in years!!!!!!!!!!!!!!!!! I think this combo will work.

Caravaggio wrote:

Farshad wrote:best sleep ive had in years!!!!!!!!!!!!!!!!! I think this combo will work.

Which combo?

Did you already rule out low or high histamine?

Diamine oxidase for high histamine, L-Histidine for low histamine.

Curr Neuropharmacol. 2010 Sep; 8(3): 161.
Melatonin and Brain
Dun-Xian Tan

Caravaggio wrote:Farshad could you please do another test: Saliva melatonin.

I think it is a very good indicator of serotonin as serotonin is converted to melatonin in the brain and melatonin easily crosses the blood-brain-barrier (both ways) in contrast to serotonin which doesn't.

Curr Neuropharmacol. 2010 Sep; 8(3): 161.
Melatonin and Brain
Dun-Xian Tan

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001209/

My saliva melatonin is: <0,50 pg/ml (taken right before bed) with the ranges <=5 pg/ml during the day, ~10 pg/ml in the evening and ~20 pg/ml during the night.

So it fits with my suspicion of low serotonin.

If you have high serotonin, your levels should be way over 20 pg/ml (when measuring before bed).