Rosemarinic Acid / Butterbur combination; a natural remedy for anxiety addressing where others have failed?

A very unique mechanism of action as well; rosemarinic acid sports GABA Transaminase inhibition; meaning it stops the reuptake of GABA and allows GABA to function better....

Since many individuals with anxiety disorders lack GABA, or the usage thereof, this may be an important asset to those in need.

It would be highly synergistic with something like magnolia extract!

I particularly would recommend rosemarinic acid extract with butterbur combination product, especially to those who also have allergies and OCD; seemed to help my OCD a lot.

http://onlinelibrary.wiley.com/doi/10.1002/ptr.2712/abstract;jsessionid=132F82520B81BA8E29AFC8735AA99E7B.f01t01

Keywords:
lemon balm;GABA transaminase;rosmarinic acid;ursolic acid;oleanolic acid
Abstract
A novel pharmacological mechanism of action for the anxiolytic botanical Melissa officinalis L. (lemon balm) is reported. The methanol extract was identified as a potent in vitro inhibitor of rat brain GABA transaminase (GABA-T), an enzyme target in the therapy of anxiety, epilepsy and related neurological disorders. Bioassay-guided fractionation led to the identification and isolation of rosmarinic acid (RA) and the triterpenoids, ursolic acid (UA) and oleanolic acid (OA) as active principles. Phytochemical characterization of the crude extract determined RA as the major compound responsible for activity (40% inhibition at 100 µg/mL) since it represented approximately 1.5% of the dry mass of the leaves. Synergistic effects may also play a role. Copyright © 2009 John Wiley & Sons, Ltd.

seems withdrawn from sale everywhere.

So does combination of separate products butterbur and rosermarinic acid work as well, i presume?





Otherwise, i confused about mine case, i read your recent articles about ocd.

the thing, many years ago, 5 or around so, i often had ocd thought from time to time.

But, then, one day,  i had also, what i believe is, depersonalization syndrom after especially strong, i think, ocd episode. It was long time ago, but i think it was what happened presumably. It relieve on next day, but i had since some of kind ahnedonia. So it seems kind of like in recent article mentioned implication ocd relation with ahnedonia.
I tried to best of mine power to relieve it, ahnedonia symptom. It is not complete blunt, but it is far from what experienced before. Emotion particularly.


something like significantly lower sensitivity to emotions. I get use to it and deal with it, but will be glad to relieve it if it is possible and increase range and potency of emotional reactions. I had other goals, but right now ahnedonia top priority.




So, does this rosmaric butterbur combination, could help in mine case?
Or am i have to strive to implement more optimal solution plan?
Excuse me for asking here.



P.s.: Many things changed, but back then, i had lets say, horrible habits  dietic and otherwhise. And, i guess, prepossessing  rich  environment for developing ocd in general.


In my futile attempt to relieve symptoms of ahnedonia, i changed alot about myself.

I guess it is enough about me for now.


P.s.2: i think i still had ocd but not as often as before and as strong as cases of ocd before.

if i need to answer something to help understand my case, i am ready do mine best.

Rangiku wrote:
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Rosemarinic Acid is still available in combination with Butterbur --> https://www.iherb.com/r/Life-Extension-Butterbur-Extract-with-Standardized-Rosmarinic-Acid-60-Softgels/7909

And also you can buy plain Rosemary Extract. (https://amzn.to/2IDOpFh) which has HIGH % PERCENTAGE of Rosemarinic Acid; which is a GABA-Transaminase (reuptake) inhibitor and Acetylcholine booster (by inhibiting/blocking AChE like Donepezil/Aricept)

I answered this post in your Introduction Thread as well! If you are worried about mainly lack of Motivation and Emotions; and are also looking for increases in "Brain Plasticity" you should look into Dihexa + Rasagiline.

Here is a good article on the Topic of Neurodegeneration and Neural Plasticity --> https://www.fightaging.org/archives/2012/10/treating-neurodegeneration-by-increasing-neural-plasticity/

Dihexa Study --> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201273/

The consider this article --> Reconsidering Anhedonia in Depression: Lessons from Translational Neuroscience : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005986/

Study on Dihexa --> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466175/