Hi,
I suffer from emotional blunting and sexual dysfunction, PSSD, after I used Paroxetine for 3 months 1,5 years ago. Before that I had used Sertraline with no post-use side effects. Any comments or suggestion on treatment are truly appreciated!
My symptoms are:
Much less libodo, less sensitive, less erection, more watery semen etc in comparsion to before SSRI. No contact with penis, penis feel remote, numb, do not feel anything when I urinate. Also I am emotionally numb, cannot feel those deep sensations of joy, less sensation on skin (cold water is not as cold) and sensual aspect of touch, some hairloss. Do not get aroused by naked bodies, images etc. Feel isolated from the world and not in contact with other people, family does not feel close. Not motivated in career or life in general. Faint and light heartbeat, not strong as it used to be. Difficulty in word finding, tired brain, brain fog. Difficulty assimilating new information, memory loss. Lack of dreaming. Loss of appetite.
I also have taken a genetics test through 23andMe and below are the results for methylation and detox. I am thinking about supplementing for MTHFR but do not know how yet. Also I thinking about if the liver could not detox properly from the drug. Below is also bloodwork. Let me know if any other results could be relevant.
I am eating paleo-ish and living a normal healthy life, doing therapy and are on my way feeling psychologically better (I think and hope). I have not tried any strong supplements. Choline made things better, at least for a while I think. Sleep deprivation from severe jet lag also make me fell emotional. Chinese medicine also lifted things for a while, at the same time as heart beat got stronger by the herbs I recall.
Blood test:
S-Testosteron 22nmol/L (range 8,6-29)
S-T3 (free) 5,1pmol/L (3,5-5,4)
S-Follitropin(FSH) 1,3E/L (1,0-12,5)
S-Lutropin (LH) 2,7E/L (1,2-9,6)
Thyriod (levels were increased 1 year after SSRI compared to 1 year before SSRI)
S-TSH, tyrotropin 2,5mE/L (1,5mE/L before SSRI) (0,4-3,5)
S-T4 (free) 11pmol/L (10 before SSRI) (8-14)
B-LPK 6,3*10(9)/l (4,5*10(9)/l 2 years ago)
Methylation Profile (geneticgenie)
COMT V158M rs4680 GG -/-
COMT H62H rs4633 CC -/-
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 CT +/-
VDR Taq rs731236 AG +/-
MAO A R297R rs6323 T +/+
ACAT1-02 rs3741049 GG -/-
MTHFR C677T rs1801133 GG -/-
MTHFR 03 P39P rs2066470 GG -/-
MTHFR A1298C rs1801131 GT +/-
MTR A2756G rs1805087 AG +/-
MTRR A66G rs1801394 GG +/+
MTRR K350A rs162036 AA -/-
MTRR A664A rs1802059 GG -/-
BHMT-02 rs567754 CC -/-
BHMT-08 rs651852 CT +/-
AHCY-01 rs819147 TT -/-
AHCY-19 rs819171 TT -/-
CBS C699T rs234706 GG -/-
CBS A360A rs1801181 AG +/-
Heterozygous
VDR Bsm
VDR Taq
MTHFR A1298C
MTR A2756G
BHMT-08
CBS A360A
Homozygous
MAO A R297R
MTRR A66G
Detox Profile:
Heterozygous
CYP1A2 164A>C
CYP1B1 L432V
CYP1B1 R48G
CYP2C19*17
CYP2D6 S486T
CYP2D6 2850C>T
CYP3A4*3 M445T
GSTP1 I105V
SOD2 A16V
NAT2 I114T
Homozygous
NAT2 K268R
I suffer from emotional blunting and sexual dysfunction, PSSD, after I used Paroxetine for 3 months 1,5 years ago. Before that I had used Sertraline with no post-use side effects. Any comments or suggestion on treatment are truly appreciated!
My symptoms are:
Much less libodo, less sensitive, less erection, more watery semen etc in comparsion to before SSRI. No contact with penis, penis feel remote, numb, do not feel anything when I urinate. Also I am emotionally numb, cannot feel those deep sensations of joy, less sensation on skin (cold water is not as cold) and sensual aspect of touch, some hairloss. Do not get aroused by naked bodies, images etc. Feel isolated from the world and not in contact with other people, family does not feel close. Not motivated in career or life in general. Faint and light heartbeat, not strong as it used to be. Difficulty in word finding, tired brain, brain fog. Difficulty assimilating new information, memory loss. Lack of dreaming. Loss of appetite.
I also have taken a genetics test through 23andMe and below are the results for methylation and detox. I am thinking about supplementing for MTHFR but do not know how yet. Also I thinking about if the liver could not detox properly from the drug. Below is also bloodwork. Let me know if any other results could be relevant.
I am eating paleo-ish and living a normal healthy life, doing therapy and are on my way feeling psychologically better (I think and hope). I have not tried any strong supplements. Choline made things better, at least for a while I think. Sleep deprivation from severe jet lag also make me fell emotional. Chinese medicine also lifted things for a while, at the same time as heart beat got stronger by the herbs I recall.
Blood test:
S-Testosteron 22nmol/L (range 8,6-29)
S-T3 (free) 5,1pmol/L (3,5-5,4)
S-Follitropin(FSH) 1,3E/L (1,0-12,5)
S-Lutropin (LH) 2,7E/L (1,2-9,6)
Thyriod (levels were increased 1 year after SSRI compared to 1 year before SSRI)
S-TSH, tyrotropin 2,5mE/L (1,5mE/L before SSRI) (0,4-3,5)
S-T4 (free) 11pmol/L (10 before SSRI) (8-14)
B-LPK 6,3*10(9)/l (4,5*10(9)/l 2 years ago)
Methylation Profile (geneticgenie)
COMT V158M rs4680 GG -/-
COMT H62H rs4633 CC -/-
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 CT +/-
VDR Taq rs731236 AG +/-
MAO A R297R rs6323 T +/+
ACAT1-02 rs3741049 GG -/-
MTHFR C677T rs1801133 GG -/-
MTHFR 03 P39P rs2066470 GG -/-
MTHFR A1298C rs1801131 GT +/-
MTR A2756G rs1805087 AG +/-
MTRR A66G rs1801394 GG +/+
MTRR K350A rs162036 AA -/-
MTRR A664A rs1802059 GG -/-
BHMT-02 rs567754 CC -/-
BHMT-08 rs651852 CT +/-
AHCY-01 rs819147 TT -/-
AHCY-19 rs819171 TT -/-
CBS C699T rs234706 GG -/-
CBS A360A rs1801181 AG +/-
Heterozygous
VDR Bsm
VDR Taq
MTHFR A1298C
MTR A2756G
BHMT-08
CBS A360A
Homozygous
MAO A R297R
MTRR A66G
Detox Profile:
Heterozygous
CYP1A2 164A>C
CYP1B1 L432V
CYP1B1 R48G
CYP2C19*17
CYP2D6 S486T
CYP2D6 2850C>T
CYP3A4*3 M445T
GSTP1 I105V
SOD2 A16V
NAT2 I114T
Homozygous
NAT2 K268R